Tissue graft rejection in mice
نویسندگان
چکیده
منابع مشابه
Graft Rejection in Sponges
Graft rejection frequencies in a population of the sponge Ectyoplasia ferox are reported in relation ta the complexity of the histocompatibility system in this species. The frequency of graft acceptance is high but we show that, despite assumptions in the literature to the contrary, this does not imply that sponges accepting each other’s grafts are genetically identical. This paper reports that...
متن کاملSkin graft rejection by beta 2-microglobulin-deficient mice
Mice homozygous for a beta 2-microglobulin (beta 2-m) gene disruption lack beta 2-m protein and are deficient for functional major histocompatibility complex class I (MHC-I) molecules. The mutant mice have normal numbers of CD4+8- T helper cells, but lack MHC-I-directed CD4-8+ cytotoxic T lymphocytes (CTLs). In this study we used the beta 2-m mutant mice to study the importance of MHC-I-directe...
متن کاملVariable hematopoietic graft rejection and graft-versus-host disease in MHC-matched strains of mice.
MHC typing for human hematopoietic cell transplantation (HCT) from unrelated donors is currently performed by using a combination of serologic and molecular techniques. It has been determined that allelic differences in human MHC molecules, revealed by nucleotide sequencing but not by serologic typing, substantially influence graft rejection and graft-versus-host disease, two serious complicati...
متن کاملGraft Rejection: Immunological Suppression
Transplantation of solid organs is the treatment of choice for most patients with end-stage organ diseases. In the absence of pharmacological immunosuppression, recognition of foreign (allogeneic) histocompatibility proteins expressedondonorcellsby therecipient’s immunesystem results in rejection of the transplanted tissue(s). One-year renal transplant survival is now routinely over 90% in most...
متن کاملCells mediating graft rejection in the mouse. I. Lyt-1 cells mediate skin graft rejection
The Ly phenotype of cells mediating skin graft rejection was determined using monoclonal anti-Lyt-1.1 and Lyt-2.1 antibodies in CBA mice that received CBA lymphoid cells from mice sensitized to C57BL/6; i.e., alloantigenic differences arising from the H-2 and non-H-2 loci. It was clear that graft rejection was due wholly to the presence of Lyt-1 cells in the inoculum and that Lyt-123 or Lyt-23 ...
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ژورنال
عنوان ژورنال: Immunogenetics
سال: 1977
ISSN: 0093-7711,1432-1211
DOI: 10.1007/bf01575670